解答:解:∵f(x)=-x2+4x=-(x-2)2+4,∴当x=2时,f(2)=4,由f(x)=-x2+4x=-5,得x2-4x-5=0,即x=5或x=-1,∴要使函数在[m,5]的值域是[-5,4],则-1≤m≤2,故选:C.